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NuSmile NeoMTA® 2 FAQs

NeoMTA 2 is a Powder & Gel system consisting of an extremely fine, inorganic Powder of tricalcium and dicalcium silicate, which is mixed with the supplied water-based Gel to initiate the setting reaction. The Powder is supplied in a protective desiccant-lined container for freshness. This material is both bioactive and radiopaque.

One important characteristic that affects the performance of MTA-type products is its stability when placed in a tooth. A way to test the product’s stability is through wash-out testing. NeoMTA products are immediately wash-out resistant. You can gently rinse and complete the restoration or cement a crown, immediately after placing NeoMTA products

• NeoMTA 2 is designed to be easier to mix.

• NeoMTA 2 has about 30% higher radiopacity than NeoMTA (6.5 vs 5.0 mm equivalent aluminum as a putty-like mixture).

• NeoMTA 2 is brighter white.


• Both products are bioactive bioceramic MTAs.

• Both products release calcium and hydroxide ions promoting the formation of hydroxyapatite from the surface to seal and support healing.

• Both products are resin-free for maximum bioactivity.

• Both products have initially high pH (alkaline/basic) when applied. Literature has shown such products to be antimicrobial in-vitro1 .

• Both products are color stable, non-staining, containing tantalum oxide (tantalite) for radiopacity. Neither NeoMTA or NeoMTA 2 contain bismuth oxide, which causes tooth discoloration2 .

• Both products are immediately wash-out resistant when placed. • Both products have low water solubility (<3%) when set.

• Both products are dimensionally stable with negligible expansion on setting.

•Both products contain extremely fine, hydraulic tri/dicalcium silicate powders.

• Both products have shorter setting time (approximately 14 minutes when mixed to a putty consistency) compared to traditional MTA.

• Both products include a proprietary Gel that allows the product to be mixed to a firm putty (like ZOE or IRM ).

1The anti-microbial effect against enterococcus faecalis and the compressive strength of two types of mineral trioxide aggregate mixed with sterile water or 2% chlorhexidine liquid. Holt DM, Watts JD, Beeson TJ, Kirkpatrick TC, Rutledge RE. J Endod. 2007 Jul;33(7):844-7. 2 Marciano MA, Duarte MA, Camilleri J. Dental discoloration caused by bismuth oxide in MTA in the presence of sodium hypochlorite. Clin Oral Investig. 2015;19(9):2201-2209.

NuSmile NeoMTA and NeoMTA 2 have the same indications:

There are 10 indications for use. Read IFU prior to use, See Right hand side of this page under "Useful Links & Downloads"

Unlike inert, resin-based materials containing some MTA,… NeoMTA products are:

• Bioactive; releases calcium and hydroxide ions from the surface, promoting the formation of hydroxyapatite to ensure bioactive sealing.

• Formulated with pure tri/dicalcium silicate powder and a radiopacifier.

• Dimensionally stable – unlike resin-based materials that shrink.

• Biocompatible, non-cytotoxic.

• More versatile, having more treatment indications.

• More radiopaque.

• Resin-free for maximum MTA concentration and maximum bioactivity. [Resinbased materials containing only some MTA-type cement have not consistently shown biocompatibility in cell cultures3,4, demonstrating a toxicity that may be attributed to incomplete resin curing.]

3 Adıgüzel M, Ahmetoğlu F, Eldeniz AÜ, Tekin MG, Göğebakan B. Comparison of cytotoxic effects of calcium silicate-based materials on human pulp fibroblasts Mehmet. J Dent Res Dent Clin Dent Prospects. 2019;13(4):241-246. 4 Collado-González M, García-Bernal D, Oñate-Sánchez RE, et al. Cytotoxicity and bioactivity of various pulpotomy materials on stem cells from human exfoliated primary teeth. Int Endod J. 2017;50 Suppl 2:e19-e30.

No: White MTAs that contain bismuth oxide as the radiopacifier (e.g. ProRoot White MTA) will cause staining. All NuSmile MTA-based products, including NeoMTA 2, contain tantalite as the radiopacifier, which does not cause staining.

No: While both Portland cement and MTA contain tricalcium silicate, they are not the same.

Portland cement is:

• An impure industrial grade construction product

• A coarse powder that sets slowly• NOT a medical device

• NOT cleared by the FDA

• NOT radiopaque

• NOT a highly refined powder.

Portland cement cannot meet the international dental standards, including ISO 6876, ISO 9917-1 or ADA 57 requirements. NuSmile NeoMTA products meet all dental quality standards and are manufactured in Houston, TX USA in an FDA-registered factory certified to ISO 13485.

When mixed to a putty:

• The radiopacity of NeoMTA is 5.0mm Al equivalent.

• The radiopacity of NeoMTA 2 is higher, 6.5mm Al equivalent.

We have one kit size for sale in the US and Canada, the 2.5 gm Professional Kit . Number of treatments:

• 25 applications using the 0.1 gm large scoop

• 50 applications using the 0.05 gm small scoop

• Large scoop – 0.1 gm, enough for a pulpotomy on one or two primary posterior teeth.

• Small scoop – 0.05 gm, enough for a pulpotomy on a primary anterior or posterior tooth, or for a direct or indirect pulp cap.

Read IFU prior to use. To obtain, See Right hand side of this page under "Useful Links & Downloads"

Yes, 4cc Gel is provided in the 2.5 gm Kit, which is more than enough Gel for the Powder. 

Yes, but make sure it's a high-quality, coated pad that doesn’t absorb water; otherwise the Gel will be absorbed by the pad. We highly recommend using a glass slab for mixing NuSmile NeoMTA products. A glass slab also provides a more stable, firmer surface for complete mixing. Glass slabs are available for purchase separately

Gel is recommended. Mixing the Powder with the Gel provides superior handling and immediate wash-out resistance so you can immediately complete the restoration with or without covering the MTA product depending on your preference.

The Gel is a water-based (>50% water) liquid with proprietary ingredients. The Gel is non-cytotoxic, non-allergenic and non-sensitizing. All the components have been used successfully in other medical implant devices. The Gel enhances the properties of the Powder/Gel mixture for better handling, longer working time, immediate wash-out resistance and easier placement.

Use the spatula sold by NuSmile or a medium stiffness metal spatula. Metal spatulas are preferred over plastic spatulas because they allow easier mixing and fast incorporation of the fine powder and gel.

The Powder/Gel ratio can be varied to suit the case and your preferred application technique.

Procedure / Approx. Gel amount required

For pulpotomies and apexification, a thicker consistency is usually preferred 1-2 drops of Gel. (Dispense 1 drop of Gel near the Powder. A second drop can be placed nearby to adjust the viscosity or to rewet the material before it sets.)

For pulp capping and base/liner, a thinner consistency is usually preferred 2 drops of Gel. (Incorporate Gel into Powder gradually until desired consistency is achieved.) 

 *The Ratio of powder to gel should be adjusted to meet clinician’s preference.

• Dispense a level scoop of Powder onto a glass slab.

• Dispense 1 drop of Gel.

• Using a medium flex spatula, pull half of the first drop into the Powder. Mix the Powder and Gel thoroughly with a spatula.

(Note: Always mix the Gel into the Powder, not the Powder into the Gel. Otherwise, the Powder can become too wet and waste may occur).

• Gradually add more Gel for desired consistency.

• If too dry, dispense another drop of gel, gradually add enough gel for desired consistency. If too wet, add more powder.

• If not using immediately, cover with dappen dish or damp cotton gauze to delay setting.(Once practiced, it takes less than 1 minute to mix to the desired consistency)

• Add a small amount of Powder (less than 1 scoop).

• Alternatively, spread out mixture to a thin layer on the glass slab to allow some drying. Then use the edge of a metal spatula to gather the material into a putty or other desired consistency.

• To prevent a sticky mixture, for future mixes use less Gel when mixing.

• Add ½ drop of Gel to gradually break up the matrix to achieve the desired consistency. This method works well before the mixture is set within the first ½ hour after mixing. Alternatively, cover the mixed MTA with a moist gauze “tent” or a dappen dish to avoid drying out.

• For a pulpotomy, liner, base or pulp cap apply a layer at least 1.5mm thick.

• For root apexification compact the NeoMTA product in the apical region to create a 3 to 5 mm apical barrier.

We recommend placing NeoMTA products with a plastics instrument, Hollenbach instrument, amalgam carrier, or an MTA carrier. The material can be gently spread with a moist cotton pellet, amalgam plugger, or ball burnisher.

Use any convenient instrument, to deliver a small cone or cylinder of NeoMTA product to the site. A Messing gun, amalgam carrier, Dovgan MTA carrier, or the MAP™ system may be used. Reversed paper points or gutta percha points can guide the putty in the root to the apex for apexification.

Working time at room temperature is about 14 minutes when mixed as a putty, and 21 minutes when mixed to a thinner consistency. The working time can be extended if needed by covering the mixed cement with a moist gauze “tent” or a dappen dish or by rehydrating the mixed material with more Gel.

• When the powder is mixed to a putty-like consistency using the gel, the resulting putty is immediately wash-out resistant.

• A thick mixture takes about 14 minutes to set within the tooth.

• A thinner, sealer-type mixture will set in about 1 hour 10 minutes.

It’s not required but a quick and easy method is to apply a layer of a flowable composite, light-cure glass ionomer, RMGI, IRM®, ZOE or any other restorative material over the NeoMTA product prior to the final tooth restoration. If you use a flowable composite that requires etching, etch the tooth, not the NeoMTA product, then proceed with the restoration.

Yes, you can complete the restoration or cement a crown immediately after placing the NeoMTA product. The NeoMTA product will harden/set underneath the restoration. The NeoMTA product is immediately wash-out resistant and dimensionally stable when placed with zero shrinkage and negligible expansion to ensure gap-free sealing.

• The products have a 3-year shelf life.

• Do not leave the Powder or Gel containers open. The Powder can absorb humidity, which reduces shelf life by increasing the set time and reducing the compressive strength. After expiration, the Gel may be too thin to be satisfactory.

No, this doesn’t help extend the shelf life, and the humidity of the refrigerator may cause the Powder to absorb more moisture and deteriorate.

Use alcohol or water for cleanup. If the MTA is completely set, soak the glass slab or instrument in vinegar or water until the cement softens.

Yes, NuSmile manufactures NeoPUTTY™, a premixed Root & Pulp bioactive bioceramic MTA paste packaged in a syringe.

• NuSmile does not manufacture a light-curing MTA. We prefer to maximize the concentration of bioactive powders in NuSmile products and deliver them in a formula that allows the bioactive powders to readily hydrate and form Ca(OH)2 for hydroxyapatite formation5 .

• Light-curable and dual-cure MTA products contain resins which dilute and inhibit the MTA’s bioactivity.

• Resins never cure 100%. Uncured resin leaves cytotoxic monomers in the MTA-resin matrix and in contact with the pulp.

• Resins shrink during curing; they are not dimensionally stable. NuSmile bioactive cements (MTAs) expand very slightly to ensure sealing.

5 Formosa L M, Mallia B, Camilleri J The chemical properties of light and chemical curing composite with mineral trioxide aggregate filler. Dent Mater. 2013 Feb;29(2):e11-9.